Tegaserod: what's old is new again

GS Sayuk, J Tack - Clinical Gastroenterology and Hepatology, 2022 - Elsevier
… the gastroenterologist a comprehensive summary of the … Cisapride was introduced worldwide
in the 1990s as a serotonin 5-… this withdrawal of tegaserod was a report by the Swiss drug

Tegaserod for the treatment of irritable bowel syndrome

VN Madia, A Messore, F Saccoliti… - Anti-Inflammatory & …, 2020 - ingentaconnect.com
… Results: Tegaserod was withdrawn in 2007 due to increased … and mucosal application of
serotonin activates local reflex … a concise summary of the abovementioned drugs used for …

An update on prucalopride in the treatment of chronic constipation

A Omer, EMM Quigley - Therapeutic advances in …, 2017 - journals.sagepub.com
tegaserod, though effective, were ultimately withdrawn due to cardiovascular adverse events
due in part to receptor non-selectivity. Highly selective serotonergic … a plausible explanation

[HTML][HTML] Efficacy and safety of 5-HT4 receptor agonist minesapride for irritable bowel syndrome with constipation in a randomized controlled trial

S Fukudo, M Nakamura, T Hamatani… - Clinical …, 2021 - Elsevier
… We did not measure lower gastrointestinal motility directly in … by treatment group using summary
statistics for baseline, each … Tegaserod was withdrawn because of its association with an …

[HTML][HTML] Disorders of gastrointestinal hypomotility

K Bielefeldt, A Tuteja, S Nusrat - F1000Research, 2016 - ncbi.nlm.nih.gov
… , was withdrawn owing to an increase in cases of ischemic colitis 99, 100 . Tegaserod, the
… earlier versions (any comments will already have been addressed in the published version). …

Targeted pharmacotherapy of irritable bowel syndrome

A Arokiadoss, HC Weber - Current Opinion in Endocrinology …, 2021 - journals.lww.com
Tegaserod appeared as safe as other drugs for IBS-C in … adverse event, resulting in study
drug discontinuation in 6.5% and 0.7… opioid receptors, gut serotonin receptors, secretagogue …

[HTML][HTML] DA-9701 (Motilitone): a multi-targeting botanical drug for the treatment of functional dyspepsia

M Jin, M Son - International Journal of Molecular Sciences, 2018 - mdpi.com
… new drug development for … withdrawal of cisapride, a 5-HT 4 agonist and 5-HT 3 antagonist,
because of its cardiovascular side effects, several serotonergic drugs including tegaserod

Pharmacotherapeutic advances for chronic idiopathic constipation in adults

G Bassotti, P Usai Satta, G Berti, M Lai… - Expert Opinion on …, 2022 - Taylor & Francis
… [Citation52], was withdrawn from the market after the report of … of tegaserod [Citation54]
led to a new approval of the drug … agents to treat gastrointestinal motility disorders [Citation66]. …

An ex vivo study to evaluate the effect of tegaserod on platelet activation and aggregation

PA Gurbel, K Bliden, SD Barnett, C Witt… - Journal of …, 2021 - journals.sagepub.com
… for the treatment of functional motility disorders of the … on platelet aggregation induced by
ADP and serotonin plus … Following the voluntary withdrawal of tegaserod due to potential CV …

Ischemic colitis as a complication of medication use: an analysis of the Federal Adverse Event Reporting System

K Bielefeldt - Digestive diseases and sciences, 2016 - Springer
… analysis, we separately examined tegaserod, alosetron. The … led to the withdrawal of alosetron
and tegaserod, respectively, … interfering with serotonin signaling in such ischemic events. …